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PNH (Paroxysmal Nocturnal Hemoglobinuria)

Treatment in Chh. Sambhajinagar

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare and potentially serious blood disorder in which red blood cells break down prematurely. This process, known as hemolysis, can lead to anemia, fatigue, blood clots, and other complications. Early diagnosis and expert hematology care are essential for managing symptoms, preventing complications, and improving quality of life.

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Paroxysmal Nocturnal Hemoglobinuria PNH

What is Paroxysmal Nocturnal Hemoglobinuria (PNH)?

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare acquired blood disorder caused by a genetic mutation in bone marrow stem cells. This mutation makes red blood cells more vulnerable to destruction by the body’s immune system.

As red blood cells break down, hemoglobin is released into the bloodstream and urine, which may cause dark-colored urine, particularly in the morning. PNH can affect red blood cells, white blood cells, and platelets, increasing the risk of anemia, infections, and blood clot formation.

Common Symptoms Paroxysmal Nocturnal Hemoglobinuria

Persistent fatigue and weakness

Shortness of breath

Dizziness Tiredness

Pale skin

Abdominal pain

Difficulty swallowing

Causes & Risk Factors

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Acquired Genetic Mutation

PNH develops due to an acquired mutation in the PIGA gene within bone marrow stem cells.

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Bone Marrow Disorders

PNH is often associated with bone marrow conditions such as: Aplastic Anemia Bone Marrow Failure Syndromes Myelodysplastic Syndromes (MDS)

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Immune-Mediated Bone Marrow Damage

Abnormal immune activity affecting bone marrow cells may contribute to the development of PNH in some individuals.

How Do We Diagnose PNH

Blood Disorder Treatment
  • Reticulocyte Count
  • Lactate Dehydrogenase (LDH) Levels
  • Bilirubin Testing
  • Haptoglobin Levels
  • Bone Marrow Examination
  • Clotting Evaluation
Leading Haematology Hospital in Chhatrapati Sambhajinagar
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Why Choose Jeevan Amrut?
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  • Experienced Haematology Specialists
  • Advanced Diagnostic Facilities
  • Personalized Treatment Plans
  • Compassionate Patient Care
  • Long-Term Monitoring & Follow-Up
  • Comprehensive Blood Disorder Management
Expert Care for Rare Blood Disorders

If you are experiencing unexplained anemia, dark urine, recurrent blood clots, or abnormal blood counts, specialized hematology evaluation is essential.

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9907 104 104

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PNH is a rare, life-threatening blood disorder in which red blood cells are destroyed prematurely due to a defect in the cell membrane, leading to anemia, clotting risk, and other complications.

Common symptoms include fatigue, dark-colored urine (especially in the morning), shortness of breath, abdominal pain, difficulty swallowing, anemia, and unexplained blood clots.

PNH is caused by an acquired mutation in bone marrow stem cells that leads to abnormal red blood cells that are more easily destroyed by the immune system.

Diagnosis is mainly done through a flow cytometry test (FLAER test), along with Complete Blood Count (CBC), LDH levels, reticulocyte count, and other supportive blood tests.

Treatment may include complement inhibitors (such as eculizumab or related therapies), blood transfusions, iron and folic acid support, anticoagulation therapy, and bone marrow transplantation in severe cases.

Jeevan Amrut Haematology Centre provides expert diagnosis, advanced flow cytometry testing, personalized treatment plans, modern targeted therapies, and comprehensive long-term care for patients with PNH.

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